“Gum disease is a chronic bacterial infection that affects the soft and hard structures supporting the teeth and is associated with inflammation. Because inflammation appears to play a major role in the development and worsening of atherosclerosis, or ‘hardening’ of blood vessels, we investigated if gum disease is associated with blockages in brain vessels and strokes caused by atherosclerosis of the brain vessels,” said Souvik Sen, M.D., M.S., M.P.H., author of both studies and professor and chair of the Department of Neurology at the University of South Carolina School of Medicine in Columbia.
Periodontal disease association with large artery atherothrombotic stroke (Oral Presentation 85)
Researchers examined 265 patients (average age of 64; 49% white; 56% male) who experienced a stroke between 2015 and 2017, analyzing whether gum disease was associated with specific types of stroke.
Large artery strokes due to intracranial atherosclerosis were twice as common in patients with gum disease as in those without gum disease;
Patients with gum disease were three times as likely to have a stroke involving blood vessels in the back of the brain, which controls vision, coordination and other vital bodily functions; and
Role of periodontal disease on intracranial atherosclerosis (Oral Presentation 136)
In 1,145 people who had not experienced a stroke, selected from the Dental Atherosclerosis Risk in Communities (DARIC) Study, researchers used two magnetic resonance images to measure blockages in arteries inside the brain. Participants were an average age of 76; 78% were white, and 55% were female. Periodontal examinations were used to classify the presence and severity of gum disease.
Arteries in the brain were severely blocked (50% or more) in 10% of participants;
People with gingivitis, inflammation of the gums, were twice as likely to have moderately severe narrowed brain arteries from plaque buildup compared to those with no gum disease; and
After adjusting for risk factors such as age, high blood pressure and high cholesterol, people with gingivitis were 2.4 times as likely to have severely blocked brain arteries.
“It’s important for clinicians to recognize that gum disease is an important source of inflammation for their patients and to work with patients to address gum disease,” Sen said
The study excluded people who had gum disease serious enough to have resulted in tooth loss.
“We are working on a current study to evaluate if treatment of gum disease can reduce its association with stroke,” Sen said.