New research from the University of Pennsylvania, in collaboration with Indiana University, published in the journal
suggested a new treatment for dental plaque.
A daily application of an iron-oxide nanoparticle-containing solution called ferumoxytol with hydrogen peroxide rinse reduced the buildup of harmful dental plaque and had a targeted effect on the bacteria largely responsible for tooth decay.
These types of nanoparticles with enzyme-like properties are sometimes known as “nanozymes” and are increasingly being explored for their potential in biomedical and environmental applications.
“We found that this approach is both precise and effective,” says Hyun (Michel) Koo, a professor in the University of Pennsylvania School of Dental Medicine.
It disrupts biofilms, particularly those formed by Streptococcus mutans, which cause caries, and it also reduced the extent of enamel decay. This is the first study we know of done in a clinical setting that demonstrates the therapeutic value of nanozymes against infectious disease.